Justinian Lane

Which does Eli Lilly care more about: Sales, or customers?

I’m leaning towards sales.

Documents from the lawsuit in Alaska, where Lilly agreed to pay $15 million to settle, contain some interesting remarks and disclosure. For instance, Lilly’s research showed some patients on Zyprexa gained as much as 80 pounds and that the incidence of high blood sugar at diabetes levels was 3.5 times higher than for placebos, Bloomberg News writes. (Emphasis added.)

Before those findings were known, docs already saw a “logical link between weight gain and diabetes,” an instruction sheet advised the sales force in 2002. “We believe it is essential to weaken this link to neutralize the diabetes/hyperglycemia issue,” Lilly wrote in the sales document. “Neutralizing any concern from our customers will be essential to the future growth of Zyprexa in the marketplace.”  [Looks like Lilly neutralized any concern for their customers long ago. – JCL]

Then, there’s this: Before the October 2007 label change, Lilly didn’t instruct its sales force to say Zyprexa’s diabetes rates were higher, former marketing director David Noesges said in a January deposition. “We will NOT proactively address the diabetes concern,” the Zyprexa sales force was advised in 2002. “The competition wins if we are distracted into talking about diabetes.”  [And the customers who took Zyprexa and got diabetes are the losers. – JCL]

Source: Zyprexa Reps Told Not To Raise Diabetes Concern // Pharmalot

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Posted at 2:58 PM, Jul 31, 2008 in Pharmaceuticals
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All lawyer gotcha is bad faith.

Posted by: Supremacy Claus | July 31, 2008 4:52 PM


I think that they always care for their sales rather than the customers.
This is a bad act by the lawyers.

Posted by: Anwalt für Erbrecht | August 1, 2008 1:06 AM

Zyprexa has generated a lot of bad press for Eli Lilly and they still have unresolved Zyprexa settlement claims.
Eli Lilly is 'reaping the whirlwind' for aggressive marketing of Zyprexa that has caused suffering and deaths.
Zyprexa is being avoided by doctors they aren't prescribing it for new patients at all anymore.
Daniel Haszard 4 year Zyprexa patient who got diabetes from it.

Posted by: Daniel Haszard | August 2, 2008 4:20 AM

Dan: How do you know Zyprexa caused your diabetes, and not the factors that are now causing a billion people to get it around the world? There is no reliable evidence Zyprexa causes diabetes in the absence of these factors.

Zyprexa agreed to a settlement. I am curious if you received any compensation from that fund, and how much you received. I will then look into how much the plaintiff lawyer made.

Posted by: Supremacy Claus | August 2, 2008 11:51 AM

Anti-Psychotic Drugs (Zyprexa) Change Metabolism Study out on Eli Lilly Zyprexa causing diabetes “Based on these findings we concluded that male rats treated with olanzapine experienced an early disruption of energy metabolism. In the study 18 male rats were randomly assigned to one of three groups: (1) those receiving the conventional antipsychotic drug haloperidol (HA); (2) those receiving the atypical antipsychotic drug olanzapine (OL); or (3) the control (CO) group which did not receive either drug. The medicines were given in food for a period of six weeks. Female rats were excluded to eliminate bias in the study since antipsychotic-induced weight gain in female rodents is likely related to an interaction of the drugs with estrogens. Testing after four weeks found that the concentration of blood sugar (as glucose) was higher in OL rats (0.87 g/l) than in CO rats (0.75 g/l) and the levels increased more rapidly after a glucose meal. Testing six weeks later found fasting blood sugar levels continued to rise in OL rats (1.46 g/l vs. 1.25 g/l in CO rats) while the level of lipids (fats) in the blood was similar for both groups. Although there was no difference in body weight gain or food intake, the proportion of fat stored in the abdominal cavity was higher in OL rats (1.63%) vs. CO rats (1.44%). The HA rats did not vary in any way with the control group at any time. They exhibited a lower blood sugar level after a glucose meal and a lower proportion of intraabdominal fat store (1.44%) than OL rats.Senior study author Dominique Hermier said, “Based on these findings we concluded that male rats treated with olanzapine (Zyprexa) experienced an early disruption of energy metabolism. This was a result of the fat tissue we observed and the impairment in blood sugar regulation which are both associated with metabolic syndrome and subsequent risk of diabetes.” Source: American Physiological Society Learn more of the dangers of Zyprexa

Posted by: Zyprexa Kills | August 2, 2008 2:54 PM

ZK: Those findings show Zyprexa has no clinically meaningful effects on glucose metabolism. All differences are tiny and meaningless.

Posted by: Supremacy Claus | August 2, 2008 3:00 PM

The American diabetes association say's up to TEN TIMES greater risk of diabetes over a non user group!

How does Zyprexa cause diabetes?

It has been "theorized" that Zyprexa causes diabetes by poisoning the pancreatic beta cells causing them to die off? (if this is true then it's really scary stuff)

On July 1, 2002, Duke University issued a Press Release about the most recent finding that links the new anti-psychotics to early onset diabetes. The team of researchers--Elizabeth A. Koller, M.D. from the FDA, and Murali Doraiswamy, M.D. from Duke-- analyzed FDA's adverse drug report database, MedWatch (which receives 10% of adverse drug reports). They identified 289 cases of diabetes in patients who had been prescribed olanzapine (a.k.a. Zyprexa), Eli Lilly's most profitable drug.

The researchers reported: "Of the 289 cases of diabetes linked to the use of olanzapine, 225 were newly diagnosed cases. One hundred patients developed ketosis (a serious complication of diabetes), and 22 people developed pancreatitis, or inflammation of the pancreas, which is a life-threatening condition. There were 23 deaths, including that of a 15-year-old adolescent who died of necrotizing pancreatitis, a condition where the pancreas breaks down and dies. Most cases (71 percent) occurred within six months of starting the drug and many cases were associated with moderate weight gain."

Posted by: Zyprexa kills | August 3, 2008 3:32 AM

If a million people take Zyprexa, finding diabetes in 289 represents a small number.

1) the ADA did not discount for the world wide epidemic of diabetes;

2) nor for the established high risk of diabetes in psychiatric patients, consistently described since the 1920's;

3) nor for the differential diagnosis of premature diabetes and pancreas damage from infections, alcohol, trauma, all more frequent in psychiatric medication;

4)nor for the mere association of weight gain, caused by the side effect of hunger.

But let's say, it is proven beyond all confounding factors that Zyprexa causes direct pancreatic damage in a few people. That is a side effect. Rare but severe side effects are common to all effective remedies. It has to be monitored, and managed, the rare instances it arises.

The damage done by undertreated mental illness is 1000 more severe. This means the choice is between patient, family, and doctor. No land pirate should be allowed to interfere with this choice by defunding the drug company, by raising the price of the medication to fund a lavish style, and worse, to give massive political power from money to the land pirate.

Patients who are damaged should receive Medicaid. Period.

Doctors sued for their use of Zyprexa and Lilly should file a cross claim against the biased ADA, to see if it is funded by insurance companies. If it is, it should be fully deterred.

Posted by: Supremacy Claus | August 3, 2008 12:55 PM

(""If a million people take Zyprexa, finding diabetes in 289 represents a small number.""")

Gross distortion of the findings by a Eli Lilly shill troll

Thousands and thousands of victims have had their lives shortened by Zyprexa

Millions have been prescribed Zyprexa who never should have been.Lilly is being sued by the Attorney General in 13 states for FRAUD

Posted by: Zyprexa kills | August 5, 2008 4:49 AM

ZK: When you make an extraordinary claim, such as 1000's have been killed, or millions have had it prescribed wrongfully, you need to provide extraordinary amount of evidence. Please, provide the evidence.

I can say, that millions have had their lives improved, and thousands have had suicide and murder prevented by its powerful anti-psychotic, anti-anger, and anti-impulsivity effects.

The idea that rent seeking lawyers and anti-drug ideologues know the self-interest of patient and doctor better than they do is absurd left wing tyranny.

Posted by: Supremacy Claus | August 5, 2008 6:43 AM

I know this is not about the drug on this but lilly does not care my son has been on Strattera a lilly product for five years and do the the lose of our bussiness we can no longer get the meds he needs so I call the lilly care phone line and they told me they could not help so much for lilly care!!!!!

Posted by: Glendene | November 19, 2008 11:53 AM